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Structurally, the RBD (R319-K537) consists of a 5-stranded antiparallel β-sheet and four disulfide linkages, Cys336-Cys361, Cys379-Cys432, Cys391-Cys525, and Cys480-Cys488, which are formed to stabilize the core structure (Figure 1 C ). No chemical synthesis route has been reported for homogenous RBD preparation.
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