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The four additional mutations that distinguish B.1.1.7-O from B.1.1.7 include one change of a single amino acid in each of the nonstructural proteins, NSP2, the polymerase NSP12, and exonuclease NSP14, and in the structural protein, N. The NSP2 and N mutations are rare, showing up in only a few hundred isolates of B.1.1.7 of the over 300,000 in the GISAID ...

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