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In addition, only 1 case report of acute kidney injury in a patient with stage 3 chronic kidney disease treated by monthly minodronate has been reported to date.47 Bisphosphonate administration might result in deterioration of bone microarchitecture due to excessive suppression of bone remodeling.48–50 Recent studies have demonstrated that long-term alendronate use induces microdamage, perforation, and weakness of the cancellous bones in ...
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