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It has been previously reported that CK18 is increased in the syncytiotrophoblast of PE placentae compared with normal placentae.35–37 Increased circulating levels of CK18 have also been reported in PE and the origin of circulating CK18 is the placental syncytiotrophoblast.35,36 The increased circulating levels of cytokeratins reflects increased shedding of damaged syncytiotrophoblast into the maternal circulation from PE placentae.35,36 Furthermore, ...
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