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ILVs play an important role during virus entry, since viral infectivity is inhibited by siRNAs against VPS4A, the ESCRT-associated ATPase involved in fission of ILVs, as well as by incubation of cells with an antibody that blocks the phospholipid lysobisphosphatidic acid (LBPA), a specific cellular component found in the membranes of ILVs and crucial for ILV formation.

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