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Tumor Hypoxia, Vascular Density, Cell Proliferation, and Apoptosis in Glioma-Bearing Mice Treated with POL5551 Alone and in Combination with B20-4.1.1 In both CT-2A and GL261 glioma, treatment with B20-4.1.1 alone increased tumor invasiveness compared to controls [twofold (P < 0.001) and 1.4-fold (P < 0.05), respectively] ( Figure 1 , C and D), also consistent with observations in GBM patients treated with bevacizumab.When ...
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