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Both ESTEEM 1 and ESTEEM 2 demonstrated a higher efficacy response relative to placebo, with differences maintained in difficult-to-treat areas, such as scalp and nail psoriasis.14,18 With respect to safety, most AEs including diarrhea, nausea and headache, are transient, mild-to-moderate in severity and have a low incidence of treatment discontinuation.14 Beyond the efficacy and safety data in psoriasis, apremilast also plays a ...
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