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In actual clinical practice, patients with COPD present with eosinophilic airway inflammation without asthma characteristics, while some patients present with asthma characteristics without meeting the ACO criteria.10 About 60% of patients with COPD may have bronchial hyperresponsiveness or reversibility without asthma.11 Patients who have ACO or COPD with asthma characteristics should be treated intensively because they predict a higher exacerbation in ...
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