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Phenotypes of frequent exacerbators had been postulated and surveyed in previous studies.3 This COPD-related phenotype has recently been described using data from the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study.4 The COPD exacerbations are clustered together in time rather than random events, and there is a high-risk period for recurrent exacerbations after the initial exacerbation.4 Le ...
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