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Studies indicate an association between methotrexate use and risk of melanoma and melanoma-specific mortality,21–23 although no dose-response association has been discovered.24 Other drugs with immunosuppressant actions, commonly used to treat these diseases, are also suggested to increase the melanoma risk.25–27 Furthermore, the propensity of certain immunosuppressants to exacerbate UVR-induced DNA damage is theorized to be responsible for a potential elevated ...
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