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Pharmacokinetic models have demonstrated that for P aeruginosa strains with MICs up to 8 mg/L, a higher ceftolozane/tazobactam dose of 3 grams every 8 hours achieves more than 90% probability of attaining a 50% time >MIC in the lung epithelial lining fluid.2 This higher dose was employed in the ASPECT-NP phase 3 trial of ceftolozane/tazobactam versus meropenem for nosocomial pneumonia, which led to ...
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    • Hospitals, doctors and medical care 100.00%

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